In this study, different ratios of mucin-grafted polyethylene-glycol-based microparticles\nwere prepared and evaluated both in vitro and in vivo as carriers for the oral delivery of insulin.\nCharacterization measurements showed that the insulin-loaded microparticles display irregular\nporosity and shape. The encapsulation efficiency and loading capacity of insulin were >82%\nand 18%, respectively. The release of insulin varied between 68% and 92% depending on the\nmicroparticle formulation. In particular, orally administered insulin-loaded microparticles resulted in\na significant fall of blood glucose levels, as compared to insulin solution. Subcutaneous administration\nshowed a faster, albeit not sustained, glucose fall within a short time as compared to the polymeric\nmicroparticle-based formulations. These results indicate the possible oral delivery of insulin using\nthis combination of polymers.
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